Michael
A. Gimbrone Jr., M.D.
Elsie T. Friedman Professor of Pathology
Harvard Medical School
Director, Center for Excellence in Vascular Biology
Brigham & Women's Hospital
77 Avenue Louis Pasteur, NRB-752
Boston, MA 02115-6110
tel (617)525-4325
fax (617)525-4326
email:
mgimbrone@rics.bwh.harvard.edu
Biographical
Sketch
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Vascular
endothelium, the single-cell-thick lining of the cardiovascular
system, forms a dynamic interface between the circulating
blood and the various tissues and organs of the body. Interactions
of endothelial cells with blood components (e.g., red cells,
platelets, leukocytes, lipoproteins), smooth muscle cells
and pericytes, and extracellular matrix are central to normal
vascular homeostasis. Abnormalities in these interactions
can contribute to the pathogenesis of acute and chronic inflammation,
thrombosis and embolism, vascular injury, angiogenesis, and
atherosclerosis. During the past 25 years, the Gimbrone Laboratory
has used a multidisciplinary approach to gain mechanistic
insights into the role of vascular endothelium in health and
disease, combining various experimental strategies-- cellular
and molecular biological, biochemical, morphological, and
molecular genetic, both in vitro and in vivo.
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