Profiling Project

Michael A. Gimbrone Jr.

Michael A. Gimbrone Jr., M.D.
Elsie T. Friedman Professor of Pathology
Harvard Medical School
Director, Center for Excellence in Vascular Biology
Brigham & Women's Hospital
77 Avenue Louis Pasteur, NRB-752
Boston, MA 02115-6110
tel (617)525-4325
fax (617)525-4326


Biographical Sketch

Research Interests

Vascular endothelium, the single-cell-thick lining of the cardiovascular system, forms a dynamic interface between the circulating blood and the various tissues and organs of the body. Interactions of endothelial cells with blood components (e.g., red cells, platelets, leukocytes, lipoproteins), smooth muscle cells and pericytes, and extracellular matrix are central to normal vascular homeostasis. Abnormalities in these interactions can contribute to the pathogenesis of acute and chronic inflammation, thrombosis and embolism, vascular injury, angiogenesis, and atherosclerosis. During the past 25 years, the Gimbrone Laboratory has used a multidisciplinary approach to gain mechanistic insights into the role of vascular endothelium in health and disease, combining various experimental strategies-- cellular and molecular biological, biochemical, morphological, and molecular genetic, both in vitro and in vivo.

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