Michael A. Gimbrone Jr., M.D.
Elsie T. Friedman Professor of Pathology
Harvard Medical School
Department of Pathology
Brigham & Women's Hospital
Center for Excellence in Vascular Biology
New Research Building, Rm. 0752K
77 Avenue Louis Pasteur
Boston, MA 02115
tel 617-525-4325
fax 617-525-4326

email:
mgimbrone@rics.bwh.harvard.edu

Biographical Sketch

Vascular endothelium, the single-cell-thick lining of the cardiovascular system, forms a dynamic interface between the circulating blood and the various tissues and organs of the body. Interactions of endothelial cells with blood components (e.g., red cells, platelets, leukocytes, lipoproteins), smooth muscle cells and pericytes, and extracellular matrix are central to normal vascular homeostasis. Abnormalities in these interactions can contribute to the pathogenesis of acute and chronic inflammation, thrombosis and embolism, vascular injury, angiogenesis, and atherosclerosis. During the past 25 years, the Gimbrone Laboratory has used a multidisciplinary approach to gain mechanistic insights into the role of vascular endothelium in health and disease, combining various experimental strategies-- cellular and molecular biological, biochemical, morphological, and molecular genetic, both in vitro and in vivo.

• Student Research Takes Stage at Soma Weiss Day
• Blood Flow Mechanics Affect Genetics in Vascular Cells
• At the NRB, Faculty View Convergence of Biology and Medicine
• Endothelial Cells Mount Genetic Response To Shifting Currents in the Blood