Profiling Project


Selected Publications

PubMed Search: Gimbrone

Abstract Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, Garcia-Cardena G, Gimbrone MA Jr. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14871-6. Epub 2004 Oct 4. PMID: 15466704 [PubMed - indexed for MEDLINE]
Abstract Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosezweig A, Sessa WC, Gimbrone MA, Ertl G, Huang PL.The role of endothelial nitric oxide synthase (eNOS) in endothelial activation: insights from eNOS-knockout endothelial cells. Am J Physiol Cell Physiol. 2004 Jan 28 [Epub ahead of print]
Abstract Kwei S, Stavrakis G, Takahas M, Taylor G, Folkman MJ, Gimbrone MA Jr, Garcia-Cardena G. Early adaptive responses of the vascular wall during venous arterialization in mice. Am J Pathol. 2004 Jan;164(1):81-9.
Abstract Kiely JM, Hu Y, Garcia-Cardena G, Gimbrone MA Jr. Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma. J Immunol. 2003 Sep 15;171(6):3216-24.
Abstract Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA Jr, Luscinskas FW. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May;162(5):1591-601.
Abstract Takayama K, Garcia-Cardena G, Sukhova GK, Comander J, Gimbrone MA Jr, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem 2002 Nov 15;277(46):44147-54
Abstract Blackman BR, Garcia-Cardena G, Gimbrone MA Jr. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng 2002 Aug;124(4):397-407
Abstract Ochi H, Masuda J, Gimbrone MA. Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity. Eur J Immunol 2002 Jul;32(7):1821-31
Abstract Meiler SE, Hung RR, Gerszten RE, Gianetti J, Li L, Matsui T, Gimbrone MA Jr, Rosenzweig A. Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. J Mol Cell Cardiol 2002 Mar;34(3):349-59
Abstract Garcia-Cardena G, Comander JI, Blackman BR, Anderson KR, Gimbrone MA. Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis? Ann N Y Acad Sci 2001 Dec;947:1-6
Abstract Hu Y, Szente B, Kiely JM, Gimbrone MA Jr. Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation. J Biol Chem 2001 Dec 21;276(51):48549-53
Abstract Comander J, Weber GM, Gimbrone MA Jr, Garcia-Cardena G. Argus--a new database system for Web-based analysis of multiple microarray data sets. Genome Res 2001 Sep;11(9):1603-10
Abstract Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA Jr, Yasukochi Y, Numano F. Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 2001 Jul;21(7):1165-71
Abstract Garcia-Cardena G, Comander J, Anderson KR, Blackman BR, Gimbrone MA Jr. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4478-85.
Abstract Shin D, Garcia-Cardena G, Hayashi SI, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA, Anderson DJ. Expression of EphrinB2 Identifies a Stable Genetic Difference Between Arterial and Venous Vascular Smooth Muscle as Well as Endothelial Cells, and Marks Subsets of Microvessels at Sites of Adult Neovascularization. Dev Biol. 2001 Feb 15;230(2):139-150.
Abstract Gimbrone MA, Topper JN, Nagel T, Anderson KR, Garcia-Cardena G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000 May;902:230-9; discussion 239-40. Review.
Abstract Hu Y, Kiely J-M, Szente BE, Rosenzweig A, Gimbrone MA Jr. E-selectin-dependent siganling via the mitogen-activated protein kinase (MAPK) pathway in vascular endothelial cells. J Immunol. 2000;165(4):2142-8.
Abstract Galvin KM, Donovan MJ, Lynch CA, Meyer RI, Paul RJ, Lorenz JN, Fairchild-Huntress V, Dixon KL, Dunmore JH, Gimbrone, MA Jr., Falb D, Huszar D. A role for Smad6 in development and homeostasis of the cardiovascular system. Nature Genetics 2000; 24:171-174.
Abstract Nagel T, Resnick N, Dewey CF Jr., Gimbrone MA Jr. Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterio. Thromb. Vasc. Biol. 1999; 19:1825-1834.
Abstract Gerszten RE, Garcia-Zepeda E, Lim Y-C, Yoshida M, Ding HA, Gimbrone MA Jr., Luster AD, Luscinskas FW, Rosenzweig A. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999; 398:718-723.
Abstract Brown JD, DiChiara MR, Anderson KR, Gimbrone MA Jr, Topper JN. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 1999; 274(13):8797-8805.
Abstract Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA Jr. Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation, 1998; 5:153-171.
Abstract Topper JN, DiChiara MR, Brown JD, Williams AJ, Falb D, Collins T, Gimbrone MA Jr. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor b transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. USA, 1998; 95:9506-9511.
Abstract Yoshida M, Szente BE, Kiely J-M, Rosenzweig A, Gimbrone MA Jr. Phosphorylation of the cytoplasmic domain of E-selectin is regulated during leukocyte-endothelial adhesion. J Immunol. 1998; 933-941.
Abstract Topper JN, Cai J, Qiu Y, Anderson KR, Xu Y-Y, Deeds JD, Feeley R, Gimeno CJ, Woolf EA, Tayber O, Mays GG, Sampson BA, Schoen FJ, Gimbrone MA Jr., Falb D. Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. USA, 1997; 94:9314-9319.
Abstract Spragg DD, Alford DR, Greferath R, Larsen CE, Lee K-D, Gurtner GC, Cybulsky MI, Tosi PF, Nicolau C, Gimbrone MA Jr. Immunotargeting of liposomes to activated vascular endothelial cells: A strategy for site selective delivery in the cardiovascular system. Proc. Natl. Acad. Sci. USA, 1997; 94:8795-8800.
Abstract Hayashi H, Abdollah S, Qiu Y, Cai J, Xu Y-Y, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr., Wrana JL. Falb D. The MAD-related protein Smad7 associates with the TGFb receptor and functions as an antagonist of TGFb signaling. Cell 1997; 89(7):1165-1173.
Abstract Topper JN, Wasserman SM, Anderson KR, Cai J, Falb D, Gimbrone MA Jr. Expression of the bumetanide-sensitive Na-K-C1 cotransporter BSC2 is differentially regulated by fluid mechanical and inflammatory cytokine stimuli in vascular endothelium. J. Clin. Invest. 1997; 99(12):2941-2949.
Abstract Topper JN, Cai J, Falb D, Gimbrone MA Jr. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc. Natl. Acad. Sci. USA 1996; 93:10417-10422.
Abstract Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenzweig A, Resnick N, Gimbrone MA Jr. Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin-cytoskeleton. J. Cell Biol. 1996; 133(2):445-455.
Abstract Kiely JM, Cybulsky MI, Luscinskas FW, Gimbrone MA Jr. Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells. Arterioscl. Thromb. & Vasc. Biol. 1995; 15(8):1211-1218.
Abstract Khachigian LM, Resnick N, Gimbrone MA Jr., and Collins T. Nuclear Factor-kB interacts functionally with the platelet-derived growth factor B-chain shear-stress-response-element in vascular endothelial cells exposed to fluid shear stress. J. Clin. Invest. 1995; 96(2):1169-1175.

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